Achievements

Approvals for CKC-5 (triple-gene) from Punjab Seed council and CKK (five-gene) insect-resistant and weedicide-tolerant cotton variety for field trial permission from NBC

Salt-tolerant and drought-resistant cotton varieties have been successfully developed and subjected to field- testing

Developed pest resistant potato through genome editing and subjected to field evaluation

Developed True Potato Seed through breeding longer shelf-life potato and pest resistant

Discovered novel bacteriophages indigenously, that offer significant potential to combat critical health challenges such as infections caused by Multi Drug Resistant (MDR) Bacteria

miRNA-based Drug-Resistant genes silencing in cancer cell lines, were performed at molecular level

Conducted initial field trials of the larvicidal transgenic algae on the floating treatment wetlands (FTWs)

Assessed the immunogenicity of the Chlamydomonas reinhardtii expressed influenza CTB-M2e fusion protein in mice

Identified the potential therapeutic agents against Epilepsy and Parkinson’s disease and reported the four medicinal plants with potential anticancer activity

Genetic variations of 30 InDels markers in Azad Jammu and Kashmir Population were identified

Downstream process development/optimization for the process development of Filgrastim (B

FMDV polyepitope vaccine protein was expressed in E. coli, leading to successful antibody production

The compound Reserpine has been identified as a strong liver anti-fibrotic agent. The compound Reserpine ameliorated liver fibrosis by targeting the Keap1/Nrf2 pathway

The potential significance of targeting MALAT1 as a therapeutic strategy for breast cancer was identified

The compounds Betanin and Glycine Betaine downregulated expression of dengue-2 NS3 expression.

Coffea arabica extract was shown to have anti-inflammatory and antiarthritic effect in vitro and in vivo

Demonstrated that Cassia Angustifolia-primed ASCs and Plantago lanceolata and Tussilago farfara-mediated human adipose-derived stem cell therapy effectively enhance burn wound healing

Exosome investigation for tendon injury repair is in process

Developed stem cell derived exosome therapy for of liver fibrosis in rat models

Developed chitosan-sodium percarbonate-based hydrogels with sustained oxygen release, angiogenic and wound healing properties

Identification of potent senolytic drugs capable of eliminating senescent cells in in vitro diabetic cellular model

Clinical trials investigating the efficacy of ASCs supplemented with platelet rich plasma for diabetic foot ulcer patients in collaboration with JBRSC, Lahore, are ongoing with promising therapeutic outcomes

Clinical trials for Osteoarthritis and spinal cord injury patients are ongoing

Novel Variants identified in NAV3 gene, a neuronal morphogenesis protein, cause intellectual disability, developmental delay, and microcephaly

Set up commercial facilities for DNA testing, Qubit quantification and cost-effective BRCA1/2 screening for cancers

A three-gene cotton variety CEMB-AAS3 was recommended by the Varietal Evaluation Committee, PCCC

Conducted pharmacokinetics and drug toxicity studies of Semaglutide for the biopharmaceutical industry, valued at PKR 1.6 million

Produced PCR Enzymes and kits for in-house use, worth PKR 4.6 million

Revived Molecular diagnostics laboratory for hepatitis testing

Four TDF projects: PKR 46 million; twenty-six PU Projects: PKR 5.8 million; a CPEC project: PKR 12.963 million; 1 WHO project (AP24-01787): PKR 2.5 million

Ongoing: European Foundation: €125,000; Islamic Development Bank: 38.36 million PKR; Turkiye industrial: USD 25,000

Agreements and several collaborations with different institutions at National & International levels

Produced 48 M.Phil and 12 Ph.Ds. Published 89 Research Articles (impact factor of 261.614), 10 Book Chapters.

CEMB organized 28 conferences/scientific events, faculty and students actively participated in national and international conferences, symposia, seminars and training workshops.

CEMB provided internships to 53 students from institutions all over Pakistan.