Faculty profile

Dr. Muhammad Islam Khan

Assistant Professor Nutraceutical and Microbial Biotechnology Lab

Specialises in protein engineering and downstream processing of therapeutic proteins including interferon, insulin and IL-1Ra antagonist.

Assistant ProfessorCEMB · University of the Punjab
6Publications reported

Profile

Protein Engineer, Bioprocess Scientist and Educator

Dr. Muhammad Islam Khan specialises in the intersection of protein engineering and downstream processing. He has played a significant role in developing therapeutic proteins with clinical impact, including interferon, insulin, G-CSF, IL-1Ra antagonist, interleukin-29, IGF-1 and EGF, covering design, optimisation, purification and expression in yeast, bacteria and green algae.

A notable achievement is his refinement of the anti-EGFR antibody scFv, a component in targeted cancer therapies, alongside anticancer protein studies exploring how these proteins combat cancer cells.

Before joining CEMB, he worked at Shafigluco Chem on production of soluble rice protein and maltodextrin, and at AB Mauri Fermentation Pakistan on food fermentation technology, developing a comprehensive understanding of techniques that optimise taste, texture and nutritional value.

Selected contributions

Science translated into capability

01

Therapeutic protein development

Contributed to interferon, insulin, G-CSF, IL-1Ra antagonist, interleukin-29, IGF-1 and EGF development.

02

Anti-EGFR antibody refinement

Refined the anti-EGFR antibody scFv for targeted cancer therapies.

03

Industry experience

Prior roles at Shafigluco Chem (soluble rice protein, maltodextrin) and AB Mauri Fermentation Pakistan (food fermentation technology).

Research output

Selected publications

A selection of publications listed on the official CEMB faculty profile.

  1. 01
    2023 · Journal of Biotechnology

    Development of transgenic algae strain expressing CTB-M2e fusion gene, an approach towards the development of a universal edible vaccine in Algae

  2. 02
    2015 · Biotechnology and Applied Biochemistry

    Simple procedure applying lactose induction and one-step purification for high-yield production of rhCIFN

  3. 03
    2014 · Biotechnology and Applied Biochemistry

    Conditions optimization for high level expression and purification of human recombinant consensus interferon (rh cIFN) and its characterization

  4. 04
    2014 · Biotechnology and Applied Biochemistry

    Matrix-assisted refolding and purification of placenta-derived recombinant human interleukin-6 produced in Escherichia coli

  5. 05
    2014 · Molecular Biology Reports

    Expression line approach to recombinant human epidermal growth factor into the yeast, Pichia pastoris from Huh-7 cell line

  6. 06
    2014 · Yeast

    Studies to analyze the relation between IFNα2b gene dosage and its expression using Pichia pastoris based expression system

Research collaboration

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